In the Press

Important Scientific Publications

Endomyocardial Biopsy Derived Adherent Proliferating Cells – a Potential Cell Source for Cardiac Tissue Engineering
M. Haag, S. Van Linthout, S.E.A. Schröder, U. Freymann, J. Ringe, C. Tschöpe, M. Sittinger. Journal of Cellular Biochemistry; 2010

Human cardiac-derived adherent proliferating cells reduce murine acute Coxsackievirus B3-induced myocarditis
K. Miteva, M. Haag, K. Savvatis, J. Peng, K. Warstat, D. Westermann, J. Ringe, M. Sittinger, H.-P. Schultheiss, C. Tschöpe, S. Van Linthout. PlosOne; 2011

Immune attributes of cardiac-derived adherent proliferating (CAP) cells in cardiac therapy
M. Haag, M. Stolk, J. Ringe, S. Van Linthout, C. Tschöpe, M. Sittinger, M. Seifert. Journal of Tissue Engineering and Regenerative Medicine; 2012

Human Cardiac Biopsy-derived Cells Reduce Angiotensin II-induced Cardiac Remodeling
van Linthout, S., K. Miteva, P.M. Becher, M. Haag, J. Ringe, H.P. Schultheiss, M. Sittinger, and C. Tschöpe. 2012; 126: A10940. Circulation; 2012

Pro-Angiogenic Effect of Endomyocardial Biopsy-Derived Cells for Cardiac Regeneration
M. Haag, J. Ritterhoff, A. Dimura, K. Miteva, S. van Linthout, C. Tschöpe, J. Ringe, and M. Sittinger. Current Tissue Engineering. 2013

Human Endomyocardial Biopsy Specimen-Derived Stromal Cells Modulate Angiotensin II-Induced Cardiac Remodeling
K Miteva, S. Van Linthout, K Pappritz, I Müller, F Spillmann, M. Haag, H. Stachelscheid, J. Ringe, M. Sittinger, C. Tschöpe. Stem Cells Translational Medicine; 2016

The atrial appendage as a suitable source to generate cardiac-derived adherent proliferating cells for regenerative cell-based therapies.
Detert S, Stamm C, Beez C, Diedrichs F, Ringe J, Van Linthout S, Seifert M, Tschöpe C, Sittinger M, Haag M. J Tissue Eng Regen Med. 2018

The Problem

So far, heart failure in chronic heart disease (cardiomyopathy) or after myocardial infarction is not satisfactorily treatable and leads to fatal heart failure with decreasing pumping

How it works

With CardAPcells, the pumping power of a weakened heart muscle can be recovered, so that heart failure or heart transplantation can be avoided.

Our innovative cell therapy development focuses specifically on strengthening the heart muscle and the natural healing process in the heart

About us

We use novel specialised cells from the patient´s heart biopsies to treat severe heart muscle weakness in a natural way and to improve the patient's quality of life

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